The recommended dose depends on the underlying condition:
- For adults with primary hypercholesterolaemia and mixed dyslipidaemia the dose is either 140 mg every two weeks
or 420 mg once monthly.
- For children aged 10 years or older with heterozygous familial hypercholesterolaemia the dose is either 140 mg
every two weeks or 420 mg once monthly.
- For adults or children aged 10 years or older with homozygous familial hypercholesterolaemia the recommended
starting dose is 420 mg once monthly. After 12 weeks your doctor may decide to increase the dose to 420 mg every
two weeks. If you also receive apheresis, a procedure similar to dialysis where cholesterol and other fats are
removed from the blood, your doctor may decide to start you on a dose of 420 mg every two weeks to coincide with
your apheresis treatment.
- For adults with established atherosclerotic cardiovascular disease (a history of heart attack, stroke or blood
vessel problems) the dose is either 140 mg every two weeks or 420 mg once monthly.