How to use Repatha® SureClick®

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How to use Repatha® (evolocumab) SureClick® pre-filled pen

Watch the Repatha® SureClick® pre-filled pen video

Always use this medicine exactly as your doctor has told you. Check with your doctor if you are not sure. Repatha® is given as an injection under the skin (subcutaneous) using the SureClick ® pre-filled pen.
Dosing Information Great Britain (England, Scotland, Wales)
The recommended dose depends on the underlying condition:
  • For adults with primary hypercholesterolaemia and mixed dyslipidaemia the dose is either 140 mg every two weeks or 420 mg once monthly.
  • For children aged 10 years or older with heterozygous familial hypercholesterolaemia the dose is either 140 mg every two weeks or 420 mg once monthly.
  • For adults or children aged 10 years or older with homozygous familial hypercholesterolaemia the recommended starting dose is 420 mg once monthly. After 12 weeks your doctor may decide to increase the dose to 420 mg every two weeks. If you also receive apheresis, a procedure similar to dialysis where cholesterol and other fats are removed from the blood, your doctor may decide to start you on a dose of 420 mg every two weeks to coincide with your apheresis treatment.
  • For adults with established atherosclerotic cardiovascular disease (a history of heart attack, stroke or blood vessel problems) the dose is either 140 mg every two weeks or 420 mg once monthly.
Dosing Information Northern Ireland
  • For adults with primary hypercholesterolaemia and mixed dyslipidaemia and in paediatric patients aged 10 years and over with heterozygous familial hypercholesterolaemia, the dose is either 140 mg every two weeks or 420 mg once monthly.
  • For adults or paediatric patients aged 10 years and over with homozygous familial hypercholesterolaemia the recommended starting dose is 420 mg once monthly. After 12 weeks your doctor may decide to increase the dose to 420 mg every two weeks. If you also receive apheresis, a procedure similar to dialysis where cholesterol and other fats are removed from the blood, your doctor may decide to start you on a dose of 420 mg every two weeks to coincide with your apheresis treatment.
  • For adults with established atherosclerotic cardiovascular disease (a history of heart attack, stroke or peripheral artery disease) the dose is either 140 mg every two weeks or 420 mg once monthly.

Reporting Adverse Events
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the website https://yellowcard.mhra.gov.uk/ or the free Yellow Card app available from the Apple App Store or Google Play Store.
Side effects should also be reported to Amgen Limited on +44 (0) 1223 436441. By reporting side effects you can help provide more information on the safety of this medicine.

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l GBR-145-0123-80006 February 2023