What do I need to know before I start Repatha® (evolocumab)?1

What do I need to know about Repatha

Do not use Repatha® if you are allergic to evolocumab or any of the other ingredients of this medicine. The other ingredients are: proline, glacial acetic acid, polysorbate 80, sodium hydroxide and water for injections

For further information, please refer to section 6 of the Patient Information Leaflet.

Warnings and precautions

Talk to your doctor, pharmacist or nurse before using Repatha® if you have:

  • liver disease
  • severe kidney problems.

The needle cover of the glass pre-filled pen is made from dry natural rubber (a derivative of latex), which may cause allergic reactions.

Children and adolescents 

The use of Repatha® has not been studied in children under 18 years of age being treated for primary hypercholesterolaemia and mixed dyslipidaema. 

The use of Repatha® has not been studied in children under 12 years of age being treated for homozygous familial hypercholesterolaemia.

Other medicines and Repatha® 

Tell your doctor or pharmacist if you are taking, have recently taken, or might take, any other medicines.

Pregnancy and breastfeeding  

Repatha® has not been tested in pregnant women. It is not known if Repatha® will harm your unborn baby. 

Inform your doctor if you are trying to get pregnant, think you may be pregnant or become pregnant whilst taking Repatha®

It is not known whether Repatha® is found in breast milk. 

It is important to tell your doctor if you are breastfeeding or plan to do so. Your doctor will then help you decide whether to stop breastfeeding, or whether to stop taking Repatha®, considering the benefit of breastfeeding to the baby and the benefit of Repatha® to the mother.

Driving and using machines

Repatha® has no or negligible influence on the ability to drive and use machines.

Repatha® contains sodium

This medicine contains less than 1 mmol sodium (23 mg) per dose, i.e. it is essentially ‘sodium-free’ and should not affect a sodium-controlled diet.

References

  1. Repatha® (evolocumab) Summary of Product Characteristics. https://www.medicines.org.uk/emc/medicine/30628.