How do I take Repatha® (evolocumab)?

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Always use this medicine exactly as your doctor has told you. Check with your doctor if you are not sure. 

Repatha® is given as an injection under the skin (subcutaneous) using the SureClick® pre-filled pen.


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Dosing

The recommended dose depends on the underlying condition:

  • for adults with primary hypercholesterolaemia and mixed dyslipidaemia the dose is either 140 mg every two weeks or 420 mg once monthly.
  • for adults or adolescents with homozygous familial hypercholesterolaemia the recommended starting dose is 420 mg once monthly. After 12 weeks your doctor may decide to increase the dose to 420 mg every two weeks. If you also receive apheresis, a procedure similar to dialysis where cholesterol and other fats are removed from the blood, your doctor may decide to start you on a dose of 420 mg every two weeks to coincide with your apheresis treatment.
  • for adults with established atherosclerotic cardiovascular disease (a history of heart attack, stroke or blood vessel problems) the dose is either 140 mg every two weeks or 420 mg once monthly.
If your doctor prescribes a dose of 420 mg you must use three pre-filled pens because each pre-filled pen only contains 140 mg of medicine. After reaching room temperature, all injections should be given within a 30 minute period.

If your doctor decides that you or a caregiver can give the injections of Repatha®, you or your caregiver should receive training on how to prepare and inject Repatha® correctly. Do not try to inject Repatha® until you have been shown how to do it by your doctor or nurse.